HEK293T Cells Are Heterozygous for CCR5 Delta 32 Mutation

C-C chemokine receptor 5 (CCR5) is a receptor for chemokines and a co-receptor for HIV-1 entry into the target CD4+ cells. CCR5 delta 32 deletion is a loss-of-function mutation, resistant to HIV-1 infection. We tried to induce the CCR5 delta 32 mutation harnessing the genome editing technique, CRISP...

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Bibliographic Details
Published in:PLoS One
Main Authors: Qi, Chunxia, Jia, Xiaopeng, Lu, Lingling, Ma, Ping, Wei, Min
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4820142/
https://ncbi.nlm.nih.gov/pubmed/27042825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152975
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