Beneficial Effects of Anti-Interleukin-6 Antibodies on Impaired Gastrointestinal Motility, Inflammation and Increased Colonic Permeability in a Murine Model of Sepsis Are Most Pronounced When Administered in a Preventive Setup

BACKGROUND AND OBJECTIVES: During sepsis, gastrointestinal ileus, mucosal barrier dysfunction and bacterial translocation are accepted to be important triggers that can maintain or exacerbate the septic state. In the caecal ligation and puncture animal model of sepsis, we demonstrated that systemic...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Nullens, Sara, Staessens, Michael, Peleman, Cédric, Plaeke, Philip, Malhotra-Kumar, Surbhi, Francque, Sven, De Man, Joris G., De Winter, Benedicte Y.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2016
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4820138/
https://ncbi.nlm.nih.gov/pubmed/27044016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152914
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