Beneficial Effects of Anti-Interleukin-6 Antibodies on Impaired Gastrointestinal Motility, Inflammation and Increased Colonic Permeability in a Murine Model of Sepsis Are Most Pronounced When Administered in a Preventive Setup

BACKGROUND AND OBJECTIVES: During sepsis, gastrointestinal ileus, mucosal barrier dysfunction and bacterial translocation are accepted to be important triggers that can maintain or exacerbate the septic state. In the caecal ligation and puncture animal model of sepsis, we demonstrated that systemic...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Nullens, Sara, Staessens, Michael, Peleman, Cédric, Plaeke, Philip, Malhotra-Kumar, Surbhi, Francque, Sven, De Man, Joris G., De Winter, Benedicte Y.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4820138/
https://ncbi.nlm.nih.gov/pubmed/27044016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152914
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