Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss

OBJECTIVES: Rheumatoid arthritis (RA)-specific anti-citrullinated protein/peptide antibodies (ACPAs) appear before disease onset and are associated with bone destruction. We aimed to dissect the role of ACPAs in osteoclast (OC) activation and to identify key cellular mediators in this process. METHO...

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Publicado no:Ann Rheum Dis
Main Authors: Krishnamurthy, Akilan, Joshua, Vijay, Haj Hensvold, Aase, Jin, Tao, Sun, Meng, Vivar, Nancy, Ytterberg, A Jimmy, Engström, Marianne, Fernandes-Cerqueira, Cátia, Amara, Khaled, Magnusson, Malin, Wigerblad, Gustaf, Kato, Jungo, Jiménez-Andrade, Juan Miguel, Tyson, Kerry, Rapecki, Stephen, Lundberg, Karin, Catrina, Sergiu-Bogdan, Jakobsson, Per-Johan, Svensson, Camilla, Malmström, Vivianne, Klareskog, Lars, Wähämaa, Heidi, Catrina, Anca I
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2016
Assuntos:
Basic and Translational Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4819614/
https://ncbi.nlm.nih.gov/pubmed/26612338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2015-208093
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