Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss

OBJECTIVES: Rheumatoid arthritis (RA)-specific anti-citrullinated protein/peptide antibodies (ACPAs) appear before disease onset and are associated with bone destruction. We aimed to dissect the role of ACPAs in osteoclast (OC) activation and to identify key cellular mediators in this process. METHO...

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Vydáno v:Ann Rheum Dis
Hlavní autoři: Krishnamurthy, Akilan, Joshua, Vijay, Haj Hensvold, Aase, Jin, Tao, Sun, Meng, Vivar, Nancy, Ytterberg, A Jimmy, Engström, Marianne, Fernandes-Cerqueira, Cátia, Amara, Khaled, Magnusson, Malin, Wigerblad, Gustaf, Kato, Jungo, Jiménez-Andrade, Juan Miguel, Tyson, Kerry, Rapecki, Stephen, Lundberg, Karin, Catrina, Sergiu-Bogdan, Jakobsson, Per-Johan, Svensson, Camilla, Malmström, Vivianne, Klareskog, Lars, Wähämaa, Heidi, Catrina, Anca I
Médium: Artigo
Jazyk:Inglês
Vydáno: BMJ Publishing Group 2016
Témata:
Basic and Translational Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4819614/
https://ncbi.nlm.nih.gov/pubmed/26612338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2015-208093
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