Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss

OBJECTIVES: Rheumatoid arthritis (RA)-specific anti-citrullinated protein/peptide antibodies (ACPAs) appear before disease onset and are associated with bone destruction. We aimed to dissect the role of ACPAs in osteoclast (OC) activation and to identify key cellular mediators in this process. METHO...

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Dades bibliogràfiques
Publicat a:Ann Rheum Dis
Autors principals: Krishnamurthy, Akilan, Joshua, Vijay, Haj Hensvold, Aase, Jin, Tao, Sun, Meng, Vivar, Nancy, Ytterberg, A Jimmy, Engström, Marianne, Fernandes-Cerqueira, Cátia, Amara, Khaled, Magnusson, Malin, Wigerblad, Gustaf, Kato, Jungo, Jiménez-Andrade, Juan Miguel, Tyson, Kerry, Rapecki, Stephen, Lundberg, Karin, Catrina, Sergiu-Bogdan, Jakobsson, Per-Johan, Svensson, Camilla, Malmström, Vivianne, Klareskog, Lars, Wähämaa, Heidi, Catrina, Anca I
Format: Artigo
Idioma:Inglês
Publicat: BMJ Publishing Group 2016
Matèries:
Basic and Translational Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4819614/
https://ncbi.nlm.nih.gov/pubmed/26612338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2015-208093
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