Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth

Development of life-threatening cancer metastases at distant organs requires disseminated tumor cells’ adaptation to and co-evolution with the drastically different microenvironments of metastatic sites(1). Cancer cells of common origin manifest distinct gene expression patterns after metastasizing...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Zhang, Lin, Zhang, Siyuan, Yao, Jun, Lowery, Frank J., Zhang, Qingling, Huang, Wen-Chien, Li, Ping, Li, Min, Wang, Xiao, Zhang, Chenyu, Wang, Hai, Ellis, Kenneth, Cheerathodi, Mujeeburahiman, McCarty, Joseph H., Palmieri, Diane, Saunus, Jodi, Lakhani, Sunil, Huang, Suyun, Sahin, Aysegul A., Aldape, Kenneth D., Steeg, Patricia S., Yu, Dihua
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4819404/
https://ncbi.nlm.nih.gov/pubmed/26479035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature15376
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