Increased expression of A Proliferation-inducing Ligand (APRIL) in lung leukocytes and alveolar epithelial cells in COPD patients with non small cell lung cancer: a possible link between COPD and lung cancer?

BACKGROUND: Chronic Obstructive Pulmonary Disease (COPD) is characterized by an excessive activation of the adaptive immune system and, in particular, uncontrolled expansion of the B-cell pool. One of the key promoters of B cell expansion is A PRoliferation-Inducing Ligand (APRIL). APRIL has been st...

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Detalhes bibliográficos
Publicado no:Multidiscip Respir Med
Main Authors: Polverino, Francesca, Laucho-Contreras, Maria, Rojas Quintero, Joselyn, Divo, Miguel, Pinto-Plata, Victor, Sholl, Lynette, de-Torres, Juan P., Celli, Bartolome R., Owen, Caroline A.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
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Original Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4819280/
https://ncbi.nlm.nih.gov/pubmed/27047662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40248-016-0051-6
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