Characterization of the C-Terminal Nuclease Domain of Herpes Simplex Virus pUL15 as a Target of Nucleotidyltransferase Inhibitors

The natural product α-hydroxytropolones manicol and β-thujaplicinol inhibit replication of herpes simplex viruses 1 and 2 (HSV-1 and HSV-2, respectively) at nontoxic concentrations. Because these were originally developed as divalent metal-sequestering inhibitors of the ribonuclease H activity of HI...

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Udgivet i:Biochemistry
Main Authors: Masaoka, Takashi, Zhao, Haiyan, Hirsch, Danielle R., D'Erasmo, Michael P., Meck, Christine, Varnado, Brittany, Gupta, Ankit, Meyers, Marvin J., Baines, Joel, Beutler, John A., Murelli, Ryan P., Tang, Liang, Le Grice, Stuart F. J.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4819167/
https://ncbi.nlm.nih.gov/pubmed/26829613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b01254
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