Contributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents

From a risk assessment perspective, DNA-reactive agents are conventionally assumed to have genotoxic risks at all exposure levels, thus applying a linear extrapolation for low-dose responses. New approaches discussed here, including more diverse and sensitive methods for assessing DNA damage and DNA...

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Publicado en:Mutat Res Rev Mutat Res
Autores principales: Klapacz, Joanna, Pottenger, Lynn H., Engelward, Bevin P., Heinen, Christopher D., Johnson, George E., Clewell, Rebecca A., Carmichael, Paul L., Adeleye, Yeyejide, Andersen, Melvin E.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4818947/
https://ncbi.nlm.nih.gov/pubmed/27036068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrrev.2015.11.001
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