Specific pattern of maturation and differentiation in the formation of cortical tubers in tuberous sclerosis omplex (TSC): evidence from layer-specific marker expression

BACKGROUND: Tuberous sclerosis complex (TSC) is a multisystem disorder that results from mutations in the TSC1 or TSC2 genes, leading to constitutive activation of the mammalian target of rapamycin (mTOR) signaling pathway. Cortical tubers represent typical lesions of the central nervous system (CNS...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Neurodev Disord
Auteurs principaux: Mühlebner, Angelika, Iyer, Anand M., van Scheppingen, Jackelien, Anink, Jasper J., Jansen, Floor E., Veersema, Tim J., Braun, Kees P., Spliet, Wim G. M., van Hecke, Wim, Söylemezoğlu, Figen, Feucht, Martha, Krsek, Pavel, Zamecnik, Josef, Bien, Christian G., Polster, Tilman, Coras, Roland, Blümcke, Ingmar, Aronica, Eleonora
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2016
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4818922/
https://ncbi.nlm.nih.gov/pubmed/27042238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s11689-016-9142-0
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