Specific pattern of maturation and differentiation in the formation of cortical tubers in tuberous sclerosis omplex (TSC): evidence from layer-specific marker expression

BACKGROUND: Tuberous sclerosis complex (TSC) is a multisystem disorder that results from mutations in the TSC1 or TSC2 genes, leading to constitutive activation of the mammalian target of rapamycin (mTOR) signaling pathway. Cortical tubers represent typical lesions of the central nervous system (CNS...

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Vydáno v:J Neurodev Disord
Hlavní autoři: Mühlebner, Angelika, Iyer, Anand M., van Scheppingen, Jackelien, Anink, Jasper J., Jansen, Floor E., Veersema, Tim J., Braun, Kees P., Spliet, Wim G. M., van Hecke, Wim, Söylemezoğlu, Figen, Feucht, Martha, Krsek, Pavel, Zamecnik, Josef, Bien, Christian G., Polster, Tilman, Coras, Roland, Blümcke, Ingmar, Aronica, Eleonora
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2016
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4818922/
https://ncbi.nlm.nih.gov/pubmed/27042238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s11689-016-9142-0
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