Oral Administration of N-Acetyl-seryl-aspartyl-lysyl-proline Ameliorates Kidney Disease in Both Type 1 and Type 2 Diabetic Mice via a Therapeutic Regimen

Kidney fibrosis is the final common pathway of progressive kidney diseases including diabetic nephropathy. Here, we report that the endogenous antifibrotic peptide N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP), the substrate of angiotensin-converting enzyme (ACE), is an orally available peptide dru...

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Detalhes bibliográficos
Publicado no:Biomed Res Int
Main Authors: Nitta, Kyoko, Shi, Sen, Nagai, Takako, Kanasaki, Megumi, Kitada, Munehiro, Srivastava, Swayam Prakash, Haneda, Masakazu, Kanasaki, Keizo, Koya, Daisuke
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4818806/
https://ncbi.nlm.nih.gov/pubmed/27088094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/9172157
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