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Structural mechanism of ATP‐dependent DNA binding and DNA end bridging by eukaryotic Rad50

The Mre11–Rad50–Nbs1 (MRN) complex is a central factor in the repair of DNA double‐strand breaks (DSBs). The ATP‐dependent mechanisms of how MRN detects and endonucleolytically processes DNA ends for the repair by microhomology‐mediated end‐joining or further resection in homologous recombination ar...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:EMBO J
Päätekijät: Seifert, Florian Ulrich, Lammens, Katja, Stoehr, Gabriele, Kessler, Brigitte, Hopfner, Karl‐Peter
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley and Sons Inc. 2016
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4818761/
https://ncbi.nlm.nih.gov/pubmed/26896444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201592934
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