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Splicing therapeutics for Alzheimer's disease
The earliest clinical manifestation of Alzheimer's disease (AD) is cognitive impairment caused by synaptic dysfunction. ApoE4, the primary risk factor for late‐onset AD, disrupts synaptic homeostasis by impairing synaptic ApoE receptor trafficking. Alternative splicing of ApoE receptor‐2 (Apoer...
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Publicado no: | EMBO Mol Med |
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Main Authors: | , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
John Wiley and Sons Inc.
2016
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4818748/ https://ncbi.nlm.nih.gov/pubmed/26902203 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201506067 |
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