Identification of HDAC6-Selective Inhibitors of Low Cancer Cell Cytotoxicity

The histone deacetylases (HDACs) occur in 11 different isoforms, and these enzymes regulate the activity of a large number of proteins involved in cancer initiation and progression. The discovery of isoform selective HDAC inhibitors (HDACIs) is desirable, as it is likely that such compounds would av...

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Veröffentlicht in:ChemMedChem
Hauptverfasser: Gaisina, Irina N., Tueckmantel, Werner, Ugolkov, Andrey, Shen, Sida, Hoffen, Jessica, Dubrovskyi, Oleksii, Mazar, Andrew, Schoon, Renee A., Billadeau, Daniel, Kozikowski, Alan P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4818591/
https://ncbi.nlm.nih.gov/pubmed/26592932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201500456
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