Differential Sensitivities of Fast- and Slow-Cycling Cancer Cells to Inosine Monophosphate Dehydrogenase 2 Inhibition by Mycophenolic Acid

As uncontrolled cell proliferation requires nucleotide biosynthesis, inhibiting enzymes that mediate nucleotide biosynthesis constitutes a rational approach to the management of oncological diseases. In practice, however, results of this strategy are mixed and thus elucidation of the mechanisms by w...

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Vydáno v:Mol Med
Hlavní autoři: Chen, Kan, Cao, Wanlu, Li, Juan, Sprengers, Dave, Hernanda, Pratika Y, Kong, Xiangdong, van der Laan, Luc JW, Man, Kwan, Kwekkeboom, Jaap, Metselaar, Herold J, Peppelenbosch, Maikel P, Pan, Qiuwei
Médium: Artigo
Jazyk:Inglês
Vydáno: The Feinstein Institute Press 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4818251/
https://ncbi.nlm.nih.gov/pubmed/26467706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2015.00126
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