The qEEG Signature of Selective NMDA NR2B Negative Allosteric Modulators; A Potential Translational Biomarker for Drug Development

The antidepressant activity of the N-methyl-D-aspartate (NMDA) receptor channel blocker, ketamine, has led to the investigation of negative allosteric modulators (NAMs) selective for the NR2B receptor subtype. The clinical development of NR2B NAMs would benefit from a translational pharmacodynamic b...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Keavy, Deborah, Bristow, Linda J., Sivarao, Digavalli V., Batchelder, Margaret, King, Dalton, Thangathirupathy, Srinivasan, Macor, John E., Weed, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817977/
https://ncbi.nlm.nih.gov/pubmed/27035340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152729
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