Segregation of a rare TTC3 variant in an extended family with late-onset Alzheimer disease

OBJECTIVE: The genetic risk architecture of Alzheimer disease (AD) is complex with single pathogenic mutations leading to early-onset AD, while both rare and common genetic susceptibility variants contribute to the more widespread late-onset AD (LOAD); we sought to discover novel genes contributing...

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Vydáno v:Neurol Genet
Hlavní autoři: Kohli, Martin A., Cukier, Holly N., Hamilton-Nelson, Kara L., Rolati, Sophie, Kunkle, Brian W., Whitehead, Patrice L., Züchner, Stephan L., Farrer, Lindsay A., Martin, Eden R., Beecham, Gary W., Haines, Jonathan L., Vance, Jeffery M., Cuccaro, Michael L., Gilbert, John R., Schellenberg, Gerard D., Carney, Regina M., Pericak-Vance, Margaret A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Wolters Kluwer 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817909/
https://ncbi.nlm.nih.gov/pubmed/27066578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/NXG.0000000000000041
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