Case Report of a Fatal Serious Adverse Event Upon Administration of T Cells Transduced With a MART-1-specific T-cell Receptor

Here, we describe a fatal serious adverse event observed in a patient infused with autologous T-cell receptor (TCR) transduced T cells. This TCR, originally obtained from a melanoma patient, recognizes the well-described HLA-A*0201 restricted 26–35 epitope of MART-1, and was not affinity enhanced. P...

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Publicat a:Mol Ther
Autors principals: van den Berg, Joost H, Gomez-Eerland, Raquel, van de Wiel, Bart, Hulshoff, Lenie, van den Broek, Daan, Bins, Adriaan, Tan, Hanno L, Harper, Jane V, Hassan, Namir J, Jakobsen, Bent K, Jorritsma, Annelies, Blank, Christian U, Schumacher, Ton N M, Haanen, John B A G
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817886/
https://ncbi.nlm.nih.gov/pubmed/25896248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.60
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