A Comprehensive Map of CNS Transduction by Eight Recombinant Adeno-associated Virus Serotypes Upon Cerebrospinal Fluid Administration in Pigs

Cerebrospinal fluid administration of recombinant adeno-associated viral (rAAV) vectors has been demonstrated to be effective in delivering therapeutic genes to the central nervous system (CNS) in different disease animal models. However, a quantitative and qualitative analysis of transduction patte...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Mol Ther
Hauptverfasser: Sorrentino, Nicolina Cristina, Maffia, Veronica, Strollo, Sandra, Cacace, Vincenzo, Romagnoli, Noemi, Manfredi, Anna, Ventrella, Domenico, Dondi, Francesco, Barone, Francesca, Giunti, Massimo, Graham, Anne-Renee, Huang, Yan, Kalled, Susan L, Auricchio, Alberto, Bacci, Maria Laura, Surace, Enrico Maria, Fraldi, Alessandro
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817820/
https://ncbi.nlm.nih.gov/pubmed/26639405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.212
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