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Two-dimensional crystal structure of aquaporin-4 bound to the inhibitor acetazolamide
Acetazolamide (AZA) reduces the water permeability of aquaporin-4, the predominant water channel in the brain. We determined the structure of aquaporin-4 in the presence of AZA using electron crystallography. Most of the features of the 5-Å density map were consistent with those of the previously de...
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| Pubblicato in: | Microscopy (Oxf) |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4817316/ https://ncbi.nlm.nih.gov/pubmed/26908838 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmicro/dfv368 |
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