A first-in-human phase 1 study of ACE910, a novel factor VIII–mimetic bispecific antibody, in healthy subjects

ACE910 is a recombinant humanized bispecific antibody that binds to activated factor IX and factor X and mimics the cofactor function of factor VIII (FVIII). This first-in-human study examined the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of ACE910 in healthy male adults...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Uchida, Naoki, Sambe, Takehiko, Yoneyama, Koichiro, Fukazawa, Naoki, Kawanishi, Takehiko, Kobayashi, Shinichi, Shima, Midori
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Plenary Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817308/
https://ncbi.nlm.nih.gov/pubmed/26626991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-06-650226
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