Oral Delivery of Particulate Transforming Growth Factor Beta 1 and All-Trans Retinoic Acid Reduces Gut Inflammation in Murine Models of Inflammatory Bowel Disease

BACKGROUND AND AIMS: We investigated oral delivery of transforming growth factor beta 1 [TGFβ]- and all-trans retinoic acid [ATRA]-loaded microspheres as therapy for gut inflammation in murine models of inflammatory bowel disease [IBD]. METHODS: ATRA and TGFβ were separately encapsulated in poly [la...

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Publicat a:J Crohns Colitis
Autors principals: Conway, Thomas F., Hammer, Laura, Furtado, Stacia, Mathiowitz, Edith, Nicoletti, Ferdinando, Mangano, Katia, Egilmez, Nejat K., Auci, Dominick L.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2015
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817304/
https://ncbi.nlm.nih.gov/pubmed/25987350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ecco-jcc/jjv089
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