Human Paraoxonase1 Hydrolysis of Nanomolar Chlorpyrifos-oxon Concentrations is Unaffected by Phenotype or Q192R Genotype

The organophosphorus insecticide chlorpyrifos has been widely used. Its active metabolite chlorpyrifos-oxon (CPO) is a potent anticholinesterase and is detoxified by paraoxonase-1 (PON1). PON1 activity is influenced by numerous factors including a Q192R polymorphism. Using forty human blood samples...

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Veröffentlicht in:Toxicol Lett
Hauptverfasser: Coombes, R. Hunter, Meek, Edward C., Dail, Mary Beth, Chambers, Howard W., Chambers, Janice E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817274/
https://ncbi.nlm.nih.gov/pubmed/25093614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxlet.2014.07.029
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