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Gliotoxin Suppresses Macrophage Immune Function by Subverting Phosphatidylinositol 3,4,5-Trisphosphate Homeostasis

Aspergillus fumigatus, an opportunistic fungal pathogen, spreads in the environment by releasing numerous conidia that are capable of reaching the small alveolar airways of mammalian hosts. In otherwise healthy individuals, macrophages are responsible for rapidly phagocytosing and eliminating these...

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Publicado en:mBio
Autores principales: Schlam, Daniel, Canton, Johnathan, Carreño, Marvin, Kopinski, Hannah, Freeman, Spencer A., Grinstein, Sergio, Fairn, Gregory D.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817266/
https://ncbi.nlm.nih.gov/pubmed/27048806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02242-15
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