Increased Energy Expenditure, Ucp1 Expression, and Resistance to Diet-induced Obesity in Mice Lacking Nuclear Factor-Erythroid-2-related Transcription Factor-2 (Nrf2)

The NRF2 (also known as NFE2L2) transcription factor is a critical regulator of genes involved in defense against oxidative stress. Previous studies suggest that Nrf2 plays a role in adipogenesis in vitro, and deletion of the Nrf2 gene protects against diet-induced obesity in mice. Here, we demonstr...

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Vydáno v:J Biol Chem
Hlavní autoři: Schneider, Kevin, Valdez, Joshua, Nguyen, Janice, Vawter, Marquis, Galke, Brandi, Kurtz, Theodore W., Chan, Jefferson Y.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817199/
https://ncbi.nlm.nih.gov/pubmed/26841864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.673756
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