The Arf GTPase-activating Protein, ASAP1, Binds Nonmuscle Myosin 2A to Control Remodeling of the Actomyosin Network

ASAP1 regulates F-actin-based structures and functions, including focal adhesions (FAs) and circular dorsal ruffles (CDRs), cell spreading and migration. ASAP1 function requires its N-terminal BAR domain. We discovered that nonmuscle myosin 2A (NM2A) directly bound the BAR-PH tandem of ASAP1 in vitr...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Chen, Pei-Wen, Jian, Xiaoying, Heissler, Sarah M., Le, Kang, Luo, Ruibai, Jenkins, Lisa M., Nagy, Attila, Moss, Joel, Sellers, James R., Randazzo, Paul A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817181/
https://ncbi.nlm.nih.gov/pubmed/26893376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.701292
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