Cholesterol Analogs with Degradation-resistant Alkyl Side Chains Are Effective Mycobacterium tuberculosis Growth Inhibitors

Cholest-4-en-3-one, whether added exogenously or generated intracellularly from cholesterol, inhibits the growth of Mycobacterium tuberculosis when CYP125A1 and CYP142A1, the cytochrome P450 enzymes that initiate degradation of the sterol side chain, are disabled. Here we demonstrate that a 16-hydro...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Frank, Daniel J., Zhao, Yan, Wong, Siew Hoon, Basudhar, Debashree, De Voss, James J., Ortiz de Montellano, Paul R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2016
Onderwerpen:
Enzymology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817165/
https://ncbi.nlm.nih.gov/pubmed/26833565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.708172
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