Identification of a major IP(5) kinase in Cryptococcus neoformans confirms that PP-IP(5)/IP(7), not IP(6), is essential for virulence

Fungal inositol polyphosphate (IP) kinases catalyse phosphorylation of IP(3) to inositol pyrophosphate, PP-IP(5)/IP(7), which is essential for virulence of Cryptococcus neoformans. Cryptococcal Kcs1 converts IP(6) to PP-IP(5)/IP(7), but the kinase converting IP(5) to IP(6) is unknown. Deletion of a...

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Publicado en:Sci Rep
Main Authors: Li, Cecilia, Lev, Sophie, Saiardi, Adolfo, Desmarini, Desmarini, Sorrell, Tania C., Djordjevic, Julianne T.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817067/
https://ncbi.nlm.nih.gov/pubmed/27033523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep23927
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