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Non-Carriers of Reduced-Function CYP2C19 Alleles are Most Susceptible to Impairment of the Anti-Platelet Effect of Clopidogrel by Proton-Pump Inhibitors: A Pilot Study

BACKGROUND: The phenomenon of CYP2C19 polymorphism affects the metabolism of both clopidogrel and proton-pump inhibitors (PPI). However, concomitant use of both drugs may reduce the desired therapeutic effects. In this study, we evaluated whether individuals with different numbers of reduced-functio...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Acta Cardiol Sin
Main Authors: Lee, Jen-Kuang, Wu, Cho-Kai, Juang, Jyh-Ming, Tsai, Chia-Ti, Hwang, Juey-Jen, Lin, Jiuun-Lee, Chiang, Fu-Tien
פורמט: Artigo
שפה:Inglês
יצא לאור: Taiwan Society of Cardiology 2016
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816920/
https://ncbi.nlm.nih.gov/pubmed/27122952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.6515/ACS20160201A
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