Epithelial Cell-Derived a Disintegrin and Metalloproteinase-17 Confers Resistance to Colonic Inflammation Through EGFR Activation

Epithelial regeneration is a key process for the recovery from ulcerative colitis (UC). Here we demonstrate that a disintegrin and metalloproteinase-17 (ADAM17), a main sheddase for tumor necrosis factor (TNF)-α, is essential for defensive epithelial properties against UC by promoting epithelial cel...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Shimoda, Masayuki, Horiuchi, Keisuke, Sasaki, Aya, Tsukamoto, Tetsuya, Okabayashi, Koji, Hasegawa, Hirotoshi, Kitagawa, Yuko, Okada, Yasunori
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816818/
https://ncbi.nlm.nih.gov/pubmed/27077118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2016.02.007
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