Inhibition of heat shock protein 27 phosphorylation promotes sensitivity to 5-fluorouracil in colorectal cancer cells

The aim of the present study was to investigate whether the inhibition of HSP27 phosphorylation, which affects certain cellular functions, modulates sensitivity to 5-fluorouracil (5-FU) in colorectal cancer cells. Exposure to 5-FU in HCT116 and HCT15 cells expressing high levels of HSP27 with a low...

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Main Authors: MATSUNAGA, ATSUSHI, ISHII, YOSHIYUKI, TSURUTA, MASASHI, OKABAYASHI, KOJI, HASEGAWA, HIROTOSHI, KITAGAWA, YUKO
Format: Artigo
Language:Inglês
Published: D.A. Spandidos 2014
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4214436/
https://ncbi.nlm.nih.gov/pubmed/25364415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2014.2580
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