Expression of Epidermal Growth Factor Receptor Detected by Cetuximab Indicates Its Efficacy to Inhibit In Vitro and In Vivo Proliferation of Colorectal Cancer Cells

Cetuximab is a chimeric mouse–human monoclonal antibody that targets the human epidermal growth factor receptor (EGFR). However, EGFR expression determined by immunohistochemistry does not predict clinical outcomes of colorectal cancer (CRC) patients treated with cetuximab. Therefore, we evaluated t...

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Main Authors: Shigeta, Kohei, Hayashida, Tetsu, Hoshino, Yoshinori, Okabayashi, Koji, Endo, Takashi, Ishii, Yoshiyuki, Hasegawa, Hirotoshi, Kitagawa, Yuko
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3688890/
https://ncbi.nlm.nih.gov/pubmed/23824671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066302
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