Analytical Validation of a Personalized Medicine APOL1 Genotyping Assay for Nondiabetic Chronic Kidney Disease Risk Assessment

The incidence of chronic kidney disease (CKD) varies by ancestry, with African Americans (AA) having a threefold to fourfold higher rate than whites. Notably, two APOL1 alleles, termed G1 [c.(1072A>G; 1200T>G)] and G2 (c.1212_1217del6), are strongly associated with higher rates of nondiabetic...

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Vydáno v:J Mol Diagn
Hlavní autoři: Zhang, Jinglan, Fedick, Anastasia, Wasserman, Stephanie, Zhao, Geping, Edelmann, Lisa, Bottinger, Erwin P., Kornreich, Ruth, Scott, Stuart A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2016
Témata:
Regular Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816711/
https://ncbi.nlm.nih.gov/pubmed/26773863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmoldx.2015.11.003
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