Cationic Peptides and Peptidomimetics Bind Glycosaminoglycans as Potential Sema3A Pathway Inhibitors

Semaphorin3A (Sema3A) is a vertebrate-secreted protein that was initially characterized as a repulsive-guidance cue. Semaphorins have crucial roles in several diseases; therefore, the development of Sema3A inhibitors is of therapeutic interest. Sema3A interacts with glycosaminoglycans (GAGs), presum...

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Bibliografiske detaljer
Udgivet i:Biophys J
Main Authors: Corredor, Miriam, Bonet, Roman, Moure, Alejandra, Domingo, Cecilia, Bujons, Jordi, Alfonso, Ignacio, Pérez, Yolanda, Messeguer, Àngel
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2016
Fag:
Proteins
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816699/
https://ncbi.nlm.nih.gov/pubmed/27028639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.01.033
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