Endothelin-1 Mediates Brain Microvascular Dysfunction Leading to Long-Term Cognitive Impairment in a Model of Experimental Cerebral Malaria

Plasmodium falciparum infection causes a wide spectrum of diseases, including cerebral malaria, a potentially life-threatening encephalopathy. Vasculopathy is thought to contribute to cerebral malaria pathogenesis. The vasoactive compound endothelin-1, a key participant in many inflammatory processe...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Freeman, Brandi D., Martins, Yuri C., Akide-Ndunge, Oscar B., Bruno, Fernando P., Wang, Hua, Tanowitz, Herbert B., Spray, David C., Desruisseaux, Mahalia S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816336/
https://ncbi.nlm.nih.gov/pubmed/27031954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005477
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