The novel ETA receptor antagonist HJP-272 prevents cerebral microvascular hemorrhage in cerebral malaria and synergistically improves survival in combination with an artemisinin derivative

AIM: To investigate the association between vasculopathy and survival during experimental cerebral malaria (ECM), and to determine whether targeting the endothelin-1 (ET-1) pathway alone or in combination with the anti-malaria drug artemether (a semi-synthetic derivative of artemisinin) will improve...

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Autors principals: Dai, Minxian, Freeman, Brandi, Bruno, Fernando P., Shikani, Henry J., Tanowitz, Herbert B., Weiss, Louis M., Reznik, Sandra E., Stephani, Ralph A., Desruisseaux, Mahalia S.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3523882/
https://ncbi.nlm.nih.gov/pubmed/22820174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lfs.2012.07.006
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