miR-302 regulates pluripotency, teratoma formation and differentiation in stem cells via an AKT1/OCT4-dependent manner

Pluripotency makes human pluripotent stem cells (hPSCs) promising for regenerative medicine, but the teratoma formation has been considered to be a major obstacle for their clinical applications. Here, we determined that the downregulation of miR-302 suppresses the teratoma formation, hampers the se...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Li, H-L, Wei, J-F, Fan, L-Y, Wang, S-H, Zhu, L, Li, T-P, Lin, G, Sun, Y, Sun, Z-J, Ding, J, Liang, X-L, Li, J, Han, Q, Zhao, R-C-H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816169/
https://ncbi.nlm.nih.gov/pubmed/26821070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.383
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