Impact of T300A Variant of ATG16L1 on Antibacterial Response, Risk of Culture Positive Infections, and Clinical Course of Crohn's Disease

OBJECTIVES: Autophagy-related 16-like 1 (ATG16L1) deficiency leads to impaired cellular autophagy and bacterial degradation as well as an altered cytokine production. The single-nucleotide polymorphism rs2241880 (T300A) is associated with an increased risk for Crohn's disease (CD). ATG16L1 poly...

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Publicat a:Clin Transl Gastroenterol
Autors principals: Salem, Mohammad, Nielsen, Ole Haagen, Nys, Kris, Yazdanyar, Shiva, Seidelin, Jakob Benedict
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
Matèries:
Inflammatory Bowel Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816087/
https://ncbi.nlm.nih.gov/pubmed/26673830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ctg.2015.47
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