Capillary zone electrophoresis-tandem mass spectrometry detects low concentration host cell impurities in monoclonal antibodies

We have evaluated capillary zone electrophoresis-electrospray ionization-tandem mass spectrometry (CZE-ESI-MS/MS) for detection of trace amounts of host cell protein impurities in recombinant therapeutics. Compared to previously published procedures, we have optimized the buffer pH used in the forma...

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Vydáno v:Electrophoresis
Hlavní autoři: Zhu, Guijie, Sun, Liangliang, Heidbrink-Thompson, Jennifer, Kuntumalla, Srilatha, Lin, Hung-yu, Larkin, Christopher J., McGivney, James B., Dovichi, Norman J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816075/
https://ncbi.nlm.nih.gov/pubmed/26530276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/elps.201500301
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