Cell line and patient-derived xenograft models reveal elevated CDCP1 as a target in high-grade serous ovarian cancer

BACKGROUND: Development of targeted therapies for high-grade serous ovarian cancer (HGSC) remains challenging, as contributing molecular pathways are poorly defined or expressed heterogeneously. CUB-domain containing protein 1 (CDCP1) is a cell-surface protein elevated in lung, colorectal, pancreas,...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Harrington, Brittney S, He, Yaowu, Davies, Claire M, Wallace, Sarah J, Adams, Mark N, Beaven, Elizabeth A, Roche, Deborah K, Kennedy, Catherine, Chetty, Naven P, Crandon, Alexander J, Flatley, Christopher, Oliveira, Niara B, Shannon, Catherine M, deFazio, Anna, Tinker, Anna V, Gilks, C Blake, Gabrielli, Brian, Brennan, Donal J, Coward, Jermaine I, Armes, Jane E, Perrin, Lewis C, Hooper, John D
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4815773/
https://ncbi.nlm.nih.gov/pubmed/26882065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.471
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