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Azidoethoxyphenylalanine as a Vibrational Reporter and Click Chemistry Partner in Proteins

An unnatural amino acid, 4-(2-azidoethoxy)-l-phenylalanine (AePhe, 1), was designed and synthesized in three steps from known compounds in 54% overall yield. The sensitivity of the IR absorption of the azide of AePhe was established by comparison of the frequency of the asymmetric stretch vibration...

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Détails bibliographiques
Publié dans:Chemistry
Auteurs principaux: Tookmanian, Elise M., Phillips-Piro, Christine M., Fenlon, Edward E., Brewer, Scott H.
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4815431/
https://ncbi.nlm.nih.gov/pubmed/26608683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201503908
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