The statistical power and validity of Ebola vaccine trials in Sierra Leone: A simulation study of trial design and analysis

BACKGROUND: Safe and effective vaccines may help end the ongoing Ebola virus disease (EVD) epidemic in West Africa, and mitigate future outbreaks. We evaluate the statistical validity and power of randomized controlled (RCT) and stepped-wedge cluster trial (SWCT) designs in Sierra Leone, where EVD i...

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Détails bibliographiques
Publié dans:Lancet Infect Dis
Auteurs principaux: Bellan, Steven E., Pulliam, Juliet R. C., Pearson, Carl A. B., Champredon, David, Fox, Spencer J., Skrip, Laura, Galvani, Alison P., Gambhir, Manoj, Lopman, Ben A., Porco, Travis C., Meyers, Lauren Ancel, Dushoff, Jonathan
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4815262/
https://ncbi.nlm.nih.gov/pubmed/25886798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1473-3099(15)70139-8
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