The statistical power and validity of Ebola vaccine trials in Sierra Leone: A simulation study of trial design and analysis

BACKGROUND: Safe and effective vaccines may help end the ongoing Ebola virus disease (EVD) epidemic in West Africa, and mitigate future outbreaks. We evaluate the statistical validity and power of randomized controlled (RCT) and stepped-wedge cluster trial (SWCT) designs in Sierra Leone, where EVD i...

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Detalhes bibliográficos
Publicado no:Lancet Infect Dis
Main Authors: Bellan, Steven E., Pulliam, Juliet R. C., Pearson, Carl A. B., Champredon, David, Fox, Spencer J., Skrip, Laura, Galvani, Alison P., Gambhir, Manoj, Lopman, Ben A., Porco, Travis C., Meyers, Lauren Ancel, Dushoff, Jonathan
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4815262/
https://ncbi.nlm.nih.gov/pubmed/25886798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1473-3099(15)70139-8
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