Novel polymer micelle mediated co-delivery of doxorubicin and P-glycoprotein siRNA for reversal of multidrug resistance and synergistic tumor therapy

Co-delivery of chemotherapeutics and siRNA with different mechanisms in a single system is a promising strategy for effective cancer therapy with synergistic effects. In this study, a triblock copolymer micelle was prepared based on the polymer of N-succinyl chitosan–poly-L-lysine–palmitic acid (NSC...

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Publicado no:Sci Rep
Main Authors: Zhang, Chun-ge, Zhu, Wen-jing, Liu, Yang, Yuan, Zhi-qiang, Yang, Shu-di, Chen, Wei-liang, Li, Ji-zhao, Zhou, Xiao-feng, Liu, Chun, Zhang, Xue-nong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4814909/
https://ncbi.nlm.nih.gov/pubmed/27030638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep23859
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