pH Induced Conformational Transitions in the Transforming Growth Factor β-Induced Protein (TGFβIp) Associated Corneal Dystrophy Mutants

Most stromal corneal dystrophies are associated with aggregation and deposition of the mutated transforming growth factor-β induced protein (TGFβIp). The 4(th)_FAS1 domain of TGFβIp harbors ~80% of the mutations that forms amyloidogenic and non-amyloidogenic aggregates. To understand the mechanism o...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Murugan, Elavazhagan, Venkatraman, Anandalakshmi, Lei, Zhou, Mouvet, Victoria, Rui Yi Lim, Rayne, Muruganantham, Nandhakumar, Goh, Eunice, Swee Lim Peh, Gary, Beuerman, Roger W., Chaurasia, Shyam S., Rajamani, Lakshminarayanan, Mehta, Jodhbir S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4814907/
https://ncbi.nlm.nih.gov/pubmed/27030015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep23836
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