Design, synthesis, crystallization and biological evaluation of new symmetrical biscationic compounds as selective inhibitors of human Choline Kinase α1 (ChoKα1)

A novel family of compounds derivative of 1,1′-(((ethane-1,2-diylbis(oxy))bis(4,1-phenylene))bis(methylene))-bispyridinium or –bisquinolinium bromide (10a-l) containing a pair of oxygen atoms in the spacer of the linker between the biscationic moieties, were synthesized and evaluated as inhibitors o...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Schiaffino-Ortega, Santiago, Baglioni, Eleonora, Mariotto, Elena, Bortolozzi, Roberta, Serrán-Aguilera, Lucía, Ríos-Marco, Pablo, Carrasco-Jimenez, M. Paz, Gallo, Miguel A., Hurtado-Guerrero, Ramon, Marco, Carmen, Basso, Giuseppe, Viola, Giampietro, Entrena, Antonio, López-Cara, Luisa Carlota
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4814829/
https://ncbi.nlm.nih.gov/pubmed/27029499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep23793
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