VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread

The specific role of VEGFA-induced permeability and vascular leakage in physiology and pathology has remained unclear. Here we show that VEGFA-induced vascular leakage depends on signalling initiated via the VEGFR2 phosphosite Y949, regulating dynamic c-Src and VE-cadherin phosphorylation. Abolished...

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Vydáno v:Nat Commun
Hlavní autoři: Li, Xiujuan, Padhan, Narendra, Sjöström, Elisabet O., Roche, Francis P., Testini, Chiara, Honkura, Naoki, Sáinz-Jaspeado, Miguel, Gordon, Emma, Bentley, Katie, Philippides, Andrew, Tolmachev, Vladimir, Dejana, Elisabetta, Stan, Radu V., Vestweber, Dietmar, Ballmer-Hofer, Kurt, Betsholtz, Christer, Pietras, Kristian, Jansson, Leif, Claesson-Welsh, Lena
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4814575/
https://ncbi.nlm.nih.gov/pubmed/27005951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11017
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