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Lewis Acid-Promoted [2+2] Cycloadditions of Alkenes with Arylketenes

A method for the [2+2] cycloaddition of arylketenes and alkenes is presented. The process involves the in situ generation of a ketene in the presence of a Lewis acid. The utility of products is demonstrated towards the synthesis of a common scaffold found in several natural product families.

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Detalhes bibliográficos
Publicado no:Org Biomol Chem
Main Authors: Rigsbee, E. M., Zhou, C., Rasik, C. M., Sptiz, A. Z., Nichols, A. J., Brown, M. K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4814371/
https://ncbi.nlm.nih.gov/pubmed/26419921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5ob01837d
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