DCLAK11, a multi-tyrosine kinase inhibitor, exhibits potent antitumor and antiangiogenic activity in vitro

AIM: To investigate the molecular targets of DCLAK11, a novel compound discovered from a series of substituted pyridin-3-amine derivatives, and to characterize its anti-tumor properties in vitro. METHODS: Kinase inhibition was measured by an ELISA assay. Cell viability was assessed with an SRB or a...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Acta Pharmacol Sin
Prif Awduron: Guo, Xiao-bin, Chen, Xian-jie, Tong, Lin-jiang, Peng, Xia, Huang, Min, Liu, Hong-chun, Liu, Hong, Ding, Jian
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2015
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4814203/
https://ncbi.nlm.nih.gov/pubmed/26027659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2015.25
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